The Sociobehavioral Phenotype: Applying a Precision Medicine Framework to Social Determinants of Health

After defining and validating sociobehavioral phenotypes, clinicians and delivery scientists can identify which phenotypes are actionable by developing randomized trials of interventions in specific subgroups. Unlike the situation in metastatic lung cancer a decade ago, healthcare delivery scientists have an armamentarium of community-based interventions to use among selected high-risk individuals. These include home-based and visiting nurse care, telephonic case management, wireless technologies, community health workers, patient-centered medical homes, social service programs, and direct financial assistance. By examining the effect of a social service or patient engagement intervention stratified by a sociobehavioral phenotype, policy makers and clinicians can determine which subpopulations derive benefit from each intervention, which can facilitate more efficient enrollment into these interventions

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